Because of the rapid growth of interest in mining biological databases, KDD Cup 2001 was focused on data from genomics and drug design. Sufficient (yet concise) information was provided so that detailed domain knowledge was not a requirement for entry. A total of 136 groups participated to produce a total of 200 submitted predictions over the 3 tasks: 114 for Thrombin, 41 for Function, and 45 for Localization.